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生命科学系の論文のサマリーを読んでいきます。また時々趣味の読書の感想も書いていきます。

2019-02-01から1ヶ月間の記事一覧

Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche.

Nature. 2016 Feb 11;530(7589):223-7. doi: 10.1038/nature16943. Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Chen JY1,2, Miyanishi M1,2, Wang SK1,2, Yamazaki S3, Sinha R1,2, Kao KS1,2, Seita J…

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy Daisuke Nakada , Hideyuki Oguro , Boaz P. Levi , Nicole Ryan , Ayumi Kitano , Yusuke Saitoh , Makiko Takeichi , George R. Wendt & Sean J. Morrison Na…

The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia

BRIEF DEFINITIVE REPORT The developmental stage of the hematopoietic nicheregulates lineage in MLL-rearranged leukemia R. Grant Rowe1,2,3, Edroaldo Lummertz da Rocha1, Patricia Sousa1, Pavlos Missios1, Michael Morse1, William Marion1, Alen…

【読書感想】紙の月

フリーテーマの読書会に参加した際に紹介されているのを聞いて、興味を持ち本を購入しました。ストーリーだけ端的に書くと、なんとなく満たされない普通の主婦が若い男に貢ぐため勤め先の銀行のお金に手を付け、ついには1億円を横領するという話。これだけ書…

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation.

Nat Biotechnol. 2019 Feb 11. doi: 10.1038/s41587-019-0017-2. [Epub ahead of print] An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. Shah NJ1,2,3,4,5, Mao AS1,2, Shih TY1,2, Ker…

Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation.

Science. 2016 Dec 2;354(6316):1152-1155. Epub 2016 Oct 20. Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation. Taya Y1, Ota Y2, Wilkinson AC1,3, Kanazawa A1, Watarai H4,5, Kasai M1, Nakauchi H6,…

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.

Cell Stem Cell. 2018 May 3;22(5):713-725.e8. doi: 10.1016/j.stem.2018.04.002. Epub 2018 Apr 26. Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. Tadokoro Y1, Hoshii T2, Yamazaki S3, Eto K4, Ema H5, Kobayash…

Haematopoietic stem and progenitor cells from human pluripotent stem cells.

Nature. 2017 May 25;545(7655):432-438. doi: 10.1038/nature22370. Epub 2017 May 17. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Sugimura R1,2,3,4, Jha DK1,2,3,4, Han A1,2, Soria-Valles C1,2,3,4, da Rocha EL1,…

【読書感想】夜は短し恋せよ乙女

森見登美彦に初挑戦しました。独特の言い回しや文体は読みづらく感じる人もひるかもしれないが、個人的には独創的かつ細やかな表現で、登場人物の心の機微に触れるような感覚を味わうことができ、非常に楽しむことができました。古風でノスタルジックであり…

【読書感想】羊と鋼の森

学校のピアノの調律に来た調律師の仕事ぶりを見て自身も調律師を目指す青年の話。方向性は少し異なるものの同じくピアノとクラシック音楽を題材としている「蜜蜂と遠雷」の方が、壮大さや音楽・演奏の文章表現にすぐれているように思い、その点からは若干物…

Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.

Cell. 2013 Aug 29;154(5):1112-1126. doi: 10.1016/j.cell.2013.08.007. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Yamamoto R1, Morita Y2, Ooehara J1, Hamanaka S3, On…

Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation.

Cell. 2018 May 31;173(6):1535-1548.e16. doi: 10.1016/j.cell.2018.03.074. Epub 2018 Apr 26. Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation. Buenrostro JD1, Corces MR2, Lareau …

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.

Immunity. 2018 Oct 16;49(4):740-753.e7. doi: 10.1016/j.immuni.2018.08.016. Epub 2018 Oct 9. The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis. Deng M1, Tang Y2, Li W3, Wang X4, Zhang R4, Zhang X4, Zhao …

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Cell. 2018 May 31;173(6):1439-1453.e19. doi: 10.1016/j.cell.2018.05.013. Epub 2018 May 31. Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Kim MY1, Yu KR2, Kenderian S…

Identification of a lineage of multipotent hematopoietic progenitors

Identification of a lineage of multipotent hematopoietic progenitors S.J. Morrison, A.M. Wandycz, H.D. Hemmati, D.E. Wright, I.L. Weissman Development 1997 124: 1929-1939; 全てのC57BL-Thy-1.1骨髄における多能性造血前駆細胞は、3種類の細胞群…

Gene therapy improves dental manifestations in hypophosphatasia model mice.

J Periodontal Res. 2017 Jun;52(3):471-478. doi: 10.1111/jre.12412. Epub 2016 Aug 26. Gene therapy improves dental manifestations in hypophosphatasia model mice. Okawa R1, Iijima O2, Kishino M1, Okawa H1, Toyosawa S1, Sugano-Tajima H2, Shim…

Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells.

Hum Gene Ther. 2015 Dec;26(12):801-12. doi: 10.1089/hum.2015.078. Epub 2015 Nov 19. Prevention of Lethal Murine Hypophosphatasia by Neonatal ExVivo Gene Therapy Using Lentivirally Transduced Bone MarrowCells. Iijima O1, Miyake K1, Watanabe…

Regulation of embryonic haematopoietic multipotency by EZH1

Letter | Published: 17 January 2018 Regulation of embryonic haematopoietic multipotency by EZH1 Linda T. Vo , Melissa A. Kinney , Xin Liu , Yuannyu Zhang , Jessica Barragan , Patricia M. Sousa , Deepak K. Jha , Areum Han , Marcella Cesana …

Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell.

Science. 1996 Jul 12;273(5272):242-5. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Osawa M1, Hanada K, Hamada H, Nakauchi H. 造血幹細胞(HSC)は、その自己複製能と多能性を通じ、生涯を通し…

【読書感想】自負と偏見

ジェイン・オースティンの作品で、イギリス文学の傑作とされています。先日、こちらをテーマにした読書会に参加してきました。タイトルは「高慢と偏見」「プライドと偏見」などとも訳されています。 以前に一度挫折した図書で、読書会の課題となっていること…

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment

Cell Stem Cell. 2018 Apr 5;22(4):600-607.e4. doi: 10.1016/j.stem.2018.03.013. Large-Scale Clonal Analysis Resolves Aging of the MouseHematopoietic Stem Cell Compartment. Yamamoto R1, Wilkinson AC2, Ooehara J3, Lan X4, Lai CY3, Nakauchi Y3,…