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Article | Published: 10 April 2019 The bone marrow microenvironment at single-cell resolution Anastasia N. Tikhonova, Igor Dolgalev, […] Iannis Aifantis Naturevolume 569, pages222–228 (2019) 骨髄微小環境は造血において重要な役割を果たしてい…
Programmable bacteria induce durable tumor regression and systemic antitumor immunity Sreyan Chowdhury, Samuel Castro, Courtney Coker, Taylor E. Hinchliffe, Nicholas Arpaia & Tal Danino Nature Medicinevolume 25, pages1057–1063 (2019) Synth…
Cell. 2019 May 16;177(5):1319-1329.e11. doi: 10.1016/j.cell.2019.03.014. Epub 2019 Apr 4. Profiling of Pluripotency Factors in Single Cells and Early Embryos. Hainer SJ1, Bošković A2, McCannell KN3, Rando OJ2, Fazzio TG4. 細胞運命の決定は…
Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing Aysegul V. Ergen, Nathan C. Boles and Margaret A. Goodell Blood 2012 119:2500-2509; doi: https://doi.org/10.1182/blood-2011-11-391730 造血幹細胞(HSC)加齢に…
Available online 30 May 2019 In Press, Corrected ProofWhat are Corrected Proof articles? Article CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation Author links open overlay panelSadhna O.Pirya…
Nat Biotechnol. Author manuscript; available in PMC 2010 Jan 12. Defining Hematopoietic Stem and Progenitor Cell Turnover by Analysis of Histone 2B-GFP Dilution Adlen Foudi,1,2,3,4,* Konrad Hochedlinger,1,2,3,4,5,*Denille Van Buren,1,2,3 J…
Letter | Published: 29 May 2019 Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamo…
J Clin Invest. 2008 Aug;118(8):2832-44. doi: 10.1172/JCI35808. Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. Bersenev A1, Wu C, Balcerek J, Tong W. 巨核球の産生という役割以外…
Aging Cell. Author manuscript; available in PMC 2013 Dec 1. Published in final edited form as: Aging Cell. 2012 Dec; 11(6): 949–959. Published online 2012 Aug 27. doi: 10.1111/j.1474-9726.2012.00862.x PMCID: PMC3500428 NIHMSID: NIHMS394581…
Cell. 2019 Mar 7;176(6):1265-1281.e24. doi: 10.1016/j.cell.2019.01.031. Epub 2019 Feb 28. Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity. van Galen P1, Hovestadt V1, Wadsworth Ii MH2, Hughes TK2, G…
Article Quantification of Self-Renewal Capacity in Single Hematopoietic Stem Cells from Normal and Lnk-Deficient Mice Author links open overlay panelHideoEma13KazuhiroSudo13JunSeita1AzusaMatsubara1YoheiMorita1MitsujiroOsawa1KiyoshiTakatsu2…
Magy Onkol. 2017 Mar 8;61(1):36-45. Epub 2016 Apr 13. [The role of driver and subclonal mutations in pathogenesis of primary myelofibrosis]. [Article in Hungarian; Abstract available in Hungarian from the publisher] Mózes R1, Gángó A2, Boh…
Leukemia. 2019 Jan;33(1):99-109. doi: 10.1038/s41375-018-0159-0. Epub 2018 Jun 15. ASXL1/EZH2 mutations promote clonal expansion of neoplastic HSC and impair erythropoiesis in PMF. Triviai I1, Zeschke S2, Rentel J2, Spanakis M3, Scherer T2…
Chem Commun (Camb). 2019 Apr 3. doi: 10.1039/c9cc00010k. [Epub ahead of print] Cytosolic delivery of CRISPR/Cas9 ribonucleoproteins for genome editing using chitosan-coated red fluorescent protein. Qiao J1, Sun W2, Lin S2, Jin R3, Ma L4, L…
Trends Cardiovasc Med. 2019 Mar 26. pii: S1050-1738(19)30042-8. doi: 10.1016/j.tcm.2019.03.005. [Epub ahead of print] Harnessing CRISPR/Cas9 technology in cardiovascular disease. Rezaei H1, Khadempar S2, Farahani N3, Hosseingholi EZ4, Haya…
Cell. 2018 May 31;173(6):1439-1453.e19. doi: 10.1016/j.cell.2018.05.013. Epub 2018 May 31. Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Kim MY1, Yu KR2, Kenderian S…
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. Epub 2005 Sep 30. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Subramanian A1, Tamayo P, Mootha VK, Mukherjee S, Ebert BL…
Dev Cell. 2014 Jun 9;29(5):621-628. doi: 10.1016/j.devcel.2014.04.013. Effect of developmental stage of HSC and recipient on transplant outcomes. Arora N1, Wenzel PL2, McKinney-Freeman SL3, Ross SJ1, Kim PG1, Chou SS1, Yoshimoto M4, Yoder …
Cancer Cell. 2008 Jun;13(6):483-95. doi: 10.1016/j.ccr.2008.04.020. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Wei J1, Wunderlich M, Fox C, Alvarez S, Cigudosa JC, Wilhelm JS, Zheng Y, Cancelas JA, Gu Y,…
Nat Med. 2017 Nov;23(11):1352-1361. doi: 10.1038/nm.4415. Epub 2017 Oct 9. Targeting glioma stem cells through combined BMI1 and EZH2 inhibition. Jin X1,2,3, Kim LJY1,4,5,6, Wu Q1,6, Wallace LC1, Prager BC1,4,5,6,7, Sanvoranart T1, Gimple …
Comp Med. 2017 Feb; 67(1): 22–27. Published online 2017 Feb. PMCID: PMC5310621 Age-Associated Differences in Hematopoietic Stem and Progenitor Cells of Mice Samanta Gasco,1 Amaya Rando,1 Pilar Zaragoza,1 Alberto García-Redondo,2 Ana C Calv…
Hum Gene Ther. 2012 Apr;23(4):399-406. doi: 10.1089/hum.2011.148. Epub 2012 Jan 26. Successful gene therapy in utero for lethal murine hypophosphatasia. Sugano H1, Matsumoto T, Miyake K, Watanabe A, Iijima O, Migita M, Narisawa S, Millán J…
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Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20012-7. doi: 10.1073/pnas.1116110108. Epub 2011 Nov 28. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Pang WW1, Price EA, Sahoo D, Beerman …
Blood. 2018 Dec 27;132(26):2707-2721. doi: 10.1182/blood-2018-04-846220. Epub 2018 Oct 26. Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation. Jacquelin S1, Straube J1, Cooper L1, Vu …
Semin Hematol. 2017 Jan;54(1):39-42. doi: 10.1053/j.seminhematol.2016.10.004. Epub 2016 Oct 20. Age-associated changes in human hematopoietic stem cells. Pang WW1, Schrier SL2, Weissman IL3. Author information 加齢は、ヒトの造血システムの…
Am J Hematol. 2012 Sep;87(9):890-7. doi: 10.1002/ajh.23266. Epub 2012 Jun 8. Lineage switch in childhood acute leukemia: an unusual event with poor outcome. Rossi JG1, Bernasconi AR, Alonso CN, Rubio PL, Gallego MS, Carrara CA, Guitter MR,…
Blood. 2012 Mar 15;119(11):2500-9. doi: 10.1182/blood-2011-11-391730. Epub 2012 Jan 30. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Ergen AV1, Boles NC, Goodell MA. 造血幹細胞(HSC)は年齢により劇的に…
血液産生のメカニズムに関する理解は大きく進歩しているが(MPPs)のレベルでのlineage特性はあまりよくわかっていない。今回、我々は、MPP2とMPP3がmyeloid-biased MPP(myeloid系細胞への多分化能を有するMPP)であることを示す。これは、血液産生をコントロー…
【抄読会】The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia
以前も抄録和訳で取り上げたこの文献について通っている大学院ラボの抄読会で取り上げました。内容を簡単にまとめます。 ★Introduction ・白血病は年齢によってその特徴が異なる。代表的なところで言えば、小児では急性リンパ球性白血病(ALL)が多いのに対し…
