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Cancer Cell. 2003 Feb;3(2):161-71. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. So CW1, Karsunky H, Passegué E, Cozzio A, Weissman IL, Cleary ML. 混合型白血病の特異的関係は、MLLオン…
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Nature. 2016 Feb 11;530(7589):223-7. doi: 10.1038/nature16943. Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Chen JY1,2, Miyanishi M1,2, Wang SK1,2, Yamazaki S3, Sinha R1,2, Kao KS1,2, Seita J…
BRIEF DEFINITIVE REPORT The developmental stage of the hematopoietic nicheregulates lineage in MLL-rearranged leukemia R. Grant Rowe1,2,3, Edroaldo Lummertz da Rocha1, Patricia Sousa1, Pavlos Missios1, Michael Morse1, William Marion1, Alen…
Nat Biotechnol. 2019 Feb 11. doi: 10.1038/s41587-019-0017-2. [Epub ahead of print] An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. Shah NJ1,2,3,4,5, Mao AS1,2, Shih TY1,2, Ker…
Nature. 2017 May 25;545(7655):432-438. doi: 10.1038/nature22370. Epub 2017 May 17. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Sugimura R1,2,3,4, Jha DK1,2,3,4, Han A1,2, Soria-Valles C1,2,3,4, da Rocha EL1,…
Cell. 2013 Aug 29;154(5):1112-1126. doi: 10.1016/j.cell.2013.08.007. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Yamamoto R1, Morita Y2, Ooehara J1, Hamanaka S3, On…
Cell. 2018 May 31;173(6):1535-1548.e16. doi: 10.1016/j.cell.2018.03.074. Epub 2018 Apr 26. Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation. Buenrostro JD1, Corces MR2, Lareau …
Immunity. 2018 Oct 16;49(4):740-753.e7. doi: 10.1016/j.immuni.2018.08.016. Epub 2018 Oct 9. The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis. Deng M1, Tang Y2, Li W3, Wang X4, Zhang R4, Zhang X4, Zhao …
Cell. 2018 May 31;173(6):1439-1453.e19. doi: 10.1016/j.cell.2018.05.013. Epub 2018 May 31. Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Kim MY1, Yu KR2, Kenderian S…
Identification of a lineage of multipotent hematopoietic progenitors S.J. Morrison, A.M. Wandycz, H.D. Hemmati, D.E. Wright, I.L. Weissman Development 1997 124: 1929-1939; 全てのC57BL-Thy-1.1骨髄における多能性造血前駆細胞は、3種類の細胞群…
J Periodontal Res. 2017 Jun;52(3):471-478. doi: 10.1111/jre.12412. Epub 2016 Aug 26. Gene therapy improves dental manifestations in hypophosphatasia model mice. Okawa R1, Iijima O2, Kishino M1, Okawa H1, Toyosawa S1, Sugano-Tajima H2, Shim…
Hum Gene Ther. 2015 Dec;26(12):801-12. doi: 10.1089/hum.2015.078. Epub 2015 Nov 19. Prevention of Lethal Murine Hypophosphatasia by Neonatal ExVivo Gene Therapy Using Lentivirally Transduced Bone MarrowCells. Iijima O1, Miyake K1, Watanabe…
Letter | Published: 17 January 2018 Regulation of embryonic haematopoietic multipotency by EZH1 Linda T. Vo , Melissa A. Kinney , Xin Liu , Yuannyu Zhang , Jessica Barragan , Patricia M. Sousa , Deepak K. Jha , Areum Han , Marcella Cesana …
Science. 1996 Jul 12;273(5272):242-5. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Osawa M1, Hanada K, Hamada H, Nakauchi H. 造血幹細胞(HSC)は、その自己複製能と多能性を通じ、生涯を通し…
Cell Stem Cell. 2018 Apr 5;22(4):600-607.e4. doi: 10.1016/j.stem.2018.03.013. Large-Scale Clonal Analysis Resolves Aging of the MouseHematopoietic Stem Cell Compartment. Yamamoto R1, Wilkinson AC2, Ooehara J3, Lan X4, Lai CY3, Nakauchi Y3,…
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3120-5. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Cheshier SH1, Morrison SJ, Liao X, Weissman IL. 造血幹細胞(HSC)は、成熟した血液細胞を産…
Nature. 2009 Apr 16;458(7240):904-8. doi: 10.1038/nature07815. Epub 2009 Feb 11. IFNalpha activates dormant haematopoietic stem cells in vivo. Essers MA1, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A. 血液システム…
J Exp Med. 2000 Nov 6;192(9):1273-80. Age-associated characteristics of murine hematopoietic stem cells. Sudo K1, Ema H, Morita Y, Nakauchi H. 造血幹細胞(HSC)の機能が年齢を経るにつれてどのように変化していくかということはについてはあまり知…
Widespread intronic polyadenylation inactivates tumoursuppressor genes in leukaemia. Nature. 2018 Sep;561(7721):127-131. doi: 10.1038/s41586-018-0465-8. Epub 2018 Aug 27. Widespread intronic polyadenylation inactivates tumoursuppressor gen…
Metabolism. 2018 May;82:142-155. doi: 10.1016/j.metabol.2017.08.013. Epub 2017 Sep 20. Hypophosphatasia. Mornet E1. Abstract ・低ホスファターゼ症は、遺伝性の代謝性疾患である。 ・胎児期に起こる致死的なものから出生後後期おこる比較的軽度なも…
Cell Stem Cell. 2018 Nov 1;23(5):714-726.e7. doi: 10.1016/j.stem.2018.08.018. Epub 2018 Sep 27. Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity. Giambra V1, Gusscott S2, Gracias D2, Song R2, Lam SH2…
Mol Ther Methods Clin Dev. 2016 Feb 3;3:15059. Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector. Nakamura-Takahashi A1, Miyake K1, Watanabe A2, Hirai Y1, I…
Leukemia. 2004 Mar;18(3):575-83. Murine marrow cellularity and the concept of stem cell competition: geographic and quantitative determinants in stem cell biology. Colvin GA1, Lambert JF, Abedi M, Hsieh CC, Carlson JE, Stewart FM, Quesenbe…
